Detection of Peritoneal Metastasis of Gastric Cancer by Liquid Biopsy in Peripheral Blood: A Prospective Study
This study is a prospective, multi-omics, observational study aimed at detecting peritoneal metastasis of gastric cancer by combined assays for methylation of cell-free DNA (cfDNA) and other blood-based biomarkers. The study will enroll 384 participants with gastric cancer.
• Inclusion Criteria for Case Arm Participants:
‣ Age 18-74 years at the day of consenting to the study.
⁃ Able to provide a written informed consent.
⁃ No prior cancer treatment (local or systematic) with either of the following:
‣ A. Pathologically confirmed gastric cancer diagnosis within 42 days prior to blood draw.
‣ B. High suspicious for cancer diagnosis by imaging tests or other routine clinical examinations, with confirmed pathological cancer diagnosis within 42 days after the blood draw.
⁃ Diagnosis of peritoneal metastasis by laparoscopy with cytology.
• Inclusion Criteria for Control Arm Participants:
‣ Age 18-74 years at the day of consenting to the study.
⁃ Able to provide a written informed consent.
⁃ No prior cancer treatment (local or systematic) with either of the following:
‣ A. Pathologically confirmed gastric cancer diagnosis within 42 days prior to blood draw.
‣ B. High suspicious for cancer diagnosis by imaging tests or other routine clinical examinations, with confirmed pathological cancer diagnosis within 42 days after the blood draw.
⁃ No peritoneal metastasis detected by laparoscopy with cytology.